Pizza Casserole with Biscuits

If you’re looking for a Pizza Casserole With Biscuits that is cheesy, comforting, and easy enough for a busy weeknight, this is one to save. It brings together savory ground beef, pepperoni, pizza sauce, melted cheese, and golden biscuit pieces for a fun twist on classic pizza night.

I love recipes like this when I want the flavors everyone enjoys without making individual pizzas. The biscuit topping adds something extra, too—it bakes up fluffy and golden while the saucy, cheesy filling underneath stays rich and satisfying. It’s also easy to switch up with your favorite pizza toppings.

If you’ve tried pizza casseroles before and ended up with a soggy topping or a dish that felt too heavy, a few simple details can make a big difference. Keep reading to see how to get those biscuits beautifully golden and how to customize this Pizza Bake Casserole for your family.

Why You’ll Love This Recipe

• Easy weeknight dinner: Everything comes together in one baking dish.
• Pizza night with a twist: You get classic pizza flavors without making pizza dough.
• Golden biscuit topping: Refrigerated biscuits bake into a fluffy, buttery topping.
• Family-friendly: It’s easy to customize with everyone’s favorite toppings.
• Hearty and filling: Ground beef, pepperoni, cheese, and biscuits make this a satisfying meal.
• Simple ingredients: Most of the ingredients are easy to find and budget-friendly.

Ingredients

For the Pizza Filling

• 1 pound ground beef
• 1 small yellow onion, diced
• 2 cloves garlic, minced
• 1½ cups pizza sauce
• 1 teaspoon Italian seasoning
• ½ teaspoon garlic powder
• ½ teaspoon salt
• ¼ teaspoon black pepper
• 1 cup sliced pepperoni, cut in half
• 1½ cups shredded mozzarella cheese, divided
• ½ cup shredded Parmesan cheese

For the Biscuit Topping

• 1 can (16 ounces) refrigerated buttermilk biscuits
• 1 tablespoon unsalted butter, melted
• ½ teaspoon Italian seasoning
• ¼ teaspoon garlic powder
• 2 tablespoons grated Parmesan cheese

How to Make Pizza Casserole with Biscuits

1. Preheat the Oven

Preheat your oven to 375°F (190°C).

Lightly grease a 9×13-inch baking dish and set it aside.

2. Cook the Ground Beef

Heat a large skillet over medium heat. Add the ground beef and diced onion.

Cook for about 6–8 minutes, breaking the beef apart as it cooks, until browned and the onion is softened.

Drain any excess grease.

3. Season the Filling

Add the minced garlic and cook for about 30 seconds.

Stir in the pizza sauce, Italian seasoning, garlic powder, salt, and black pepper.

Let the mixture simmer for 2–3 minutes so the flavors come together.

4. Add the Pepperoni and Cheese

Stir in the sliced pepperoni.

Remove the skillet from the heat and stir in ½ cup mozzarella and the Parmesan cheese.

The mixture should be thick and saucy rather than watery.

5. Transfer to the Baking Dish

Spread the pizza filling evenly in the prepared baking dish.

Sprinkle another ½ cup mozzarella over the filling.

6. Prepare the Biscuits

Separate the refrigerated biscuits and cut each one into quarters.

Arrange the biscuit pieces evenly over the casserole, leaving a little space between some of the pieces so they can puff up while baking.

7. Add the Biscuit Topping

In a small bowl, combine the melted butter, Italian seasoning, garlic powder, and Parmesan cheese.

Brush the mixture over the biscuit pieces.

8. Bake

Bake uncovered for 25–30 minutes, or until the biscuits are puffed and golden brown and the casserole is bubbling around the edges.

If the biscuits begin browning too quickly, loosely cover the casserole with foil for the remaining baking time.

9. Rest and Serve

Remove the casserole from the oven and let it rest for 5–10 minutes.

Serve warm with extra Parmesan, red pepper flakes, or your favorite pizza toppings.

credit: allfoodierecipes

Tips for the Best Pizza Casserole

Keep the Filling Thick

A watery filling can make the biscuit topping soft. Simmer the sauce with the beef for a few minutes so excess moisture cooks away before assembling the casserole.

Cut the Biscuits Into Quarters

Smaller biscuit pieces cook more evenly and give you more golden edges throughout the casserole.

Don’t Cover While Baking

Bake the casserole uncovered so steam can escape and the biscuits have a chance to become golden and fluffy.

Don’t Bury the Biscuits

Arrange the biscuit pieces on top instead of mixing them into the filling. They need exposure to the oven’s heat to brown properly.

Let It Rest

Give the casserole a few minutes to settle after baking. This makes it easier to scoop and keeps the filling from spreading immediately across the plate.

Variations

Pepperoni Pizza Casserole

Skip the ground beef and add extra pepperoni for a simple pepperoni-focused version.

Sausage Pizza Bake

Replace the ground beef with Italian sausage for a richer flavor.

Supreme Pizza Casserole

Add mushrooms, bell peppers, onions, olives, and extra pepperoni.

Meat Lovers

Use ground beef, Italian sausage, pepperoni, and cooked bacon.

Vegetarian

Leave out the meat and add mushrooms, bell peppers, onions, spinach, and black olives.

Extra Cheesy

Add another ½ cup mozzarella or use a combination of mozzarella and provolone.

Can I Make a Bubble Up Pizza Bake?

Yes. This recipe has a similar idea to a Bubble Up Pizza Bake, where pieces of refrigerated biscuit dough puff up as they bake with a pizza-inspired filling.

Keeping the biscuit pieces mostly on top helps them brown nicely instead of becoming completely covered in sauce.

Pizza Pasta Casserole

If you prefer pasta, this can easily become a Pizza Pasta Casserole.

Cook 12 ounces of rotini, penne, or another short pasta until just al dente. Mix it with the prepared pizza filling, transfer it to the baking dish, top with mozzarella, and bake until hot and bubbling.

For the pasta version, leave out the biscuits.

Pizza Spaghetti Casserole

For a Pizza Spaghetti Casserole, replace the biscuits with cooked spaghetti. Combine the pasta with the beef, sauce, pepperoni, and cheese, then bake until the cheese is melted and golden.

What to Serve With Pizza Casserole

Since this is already a hearty meal, simple sides work best.

Serve it with:

• Green salad
• Caesar salad
• Roasted broccoli
• Garlic green beans
• Antipasto salad
• Steamed vegetables
• Fresh fruit

Make-Ahead Instructions

You can prepare the pizza filling up to 1 day ahead.

Cook the beef mixture, cool it completely, cover, and refrigerate.

When you’re ready to bake, transfer the filling to the baking dish and add freshly cut biscuit pieces just before putting it in the oven.

Adding the biscuits right before baking helps prevent them from absorbing too much moisture and becoming soggy.

Storage Tips

Store leftover casserole in an airtight container in the refrigerator for up to 3–4 days.

Reheating

For the best biscuit texture, reheat individual portions in a 350°F oven or air fryer until heated through.

The microwave works for quick reheating, but the biscuit topping will be softer.

Frequently Asked Questions

Can I use canned biscuits for pizza casserole?

Yes. Refrigerated canned biscuits are perfect for this recipe because they puff up and become golden during baking.

Can I use pizza dough instead of biscuits?

Yes, but the texture will be different. Pizza dough will give you a chewier crust, while biscuits create a soft and fluffy topping.

Can I use different meat?

Absolutely. Italian sausage, cooked chicken, bacon, or extra pepperoni can be used instead of ground beef.

Can I add vegetables?

Yes. Mushrooms, bell peppers, onions, olives, spinach, and jalapeños are all good choices.

Why are my biscuits soggy?

The filling may contain too much liquid, or the biscuit pieces may be too deeply covered by the sauce. Keep the filling fairly thick, arrange the biscuits on top, and bake the casserole uncovered.

Can I freeze pizza casserole?

The filling can be frozen, but the biscuit topping is best added fresh. Freezing and thawing the baked biscuits can make them softer.

Can I make this into a deep dish pizza casserole?

Yes. Use a deeper baking dish and build the filling with additional cheese and toppings. The biscuit version will have a fluffy topping rather than the traditional crust associated with deep-dish pizza.